শনিবার, ১০ আগস্ট, ২০১৩

Siasto Raises $750,000 To Extend Task-Management Service Into Mobile Space

siasto2Siasto has received some more support to build out its task management service with $750,000 from One Asia Investment Partners,?Y Combinator, Start Fund and other angel investors. Siasto has developed a robust platform that TechCrunch's?Eric Eldon wrote about in detail last year. Last November, the company added a news feed to the service. With the new funding, Siasto will now extend its development to focus more on its mobile collaboration service. The funding will also be used to expand its service into Asia.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/JGCUtyFCf6g/

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বৃহস্পতিবার, ১ আগস্ট, ২০১৩

How to Avoid Becoming Part of "No Vacation Nation"

The US is known for being the ?No Vacation Nation." Not only do we get less vacation time that many other countries, we are more likely not to use the vacation time we have. Nearly ? billion vacation days go unused each year in the US.

People who don?t use their vacation time are more likely to develop heart disease and depression, and are even at greater risk of death than those who do. If you don?t have any vacation plans for this summer, it?s not too late to get away. Early fall is actually my favorite time of year to travel. Once the kids are back in school prices, crowds, and temperatures go down. Before you make plans, make sure you take the best kind of vacation for you by first looking at your day-to-day lifestyle.

When Life is Routine

If your life is routine, the days seems to blend into one another, or you find yourself pondering, ?Is this all there is?? you could stand to shake things up. St. Augustine said ?The world is a book and those who do not travel read only one page.? Read another page by traveling somewhere you?ve never been before. Vacationing in the same place year after year might be pleasant (as in boring), but it won?t provide much stimulation. It won?t make you a more interesting or interested person, either.

Meeting new people, eating different foods, finding your way around unfamiliar places, and taking different modes of transportation are all ways that travel is stimulating. If you travel abroad and have to try out a new language, even better! Travel forces you to use skills that remain dormant and boosts your confidence. If you stop pushing yourself to try new things, eventually your world and confidence shrink.

When Life is Hectic

Many people have the opposite problem?their day-to-day life is crazy and stressful. These people imagine they would benefit from a more relaxing vacation. The problem with forced relaxation is that if you?re used to a hectic life, a completely unstructured vacation with days of nothingness stretched out before you will be stressful. There is no point in white-knuckling it on the beach wishing you were checking your email.

A better choice for you might be a guided tour. A tour can provide enough stimulation to hold your interest, but not much stress since all the details and arrangements are left to others. There are tours for all price ranges, age groups, interests, and levels of activity. Guided tours can be as active or cerebral as you like. You can white water raft the Grand Canyon, volunteer to save turtles in Costa Rica, or explore the art of Italy.

If independent travel has always been your style and you really can?t see yourself doing a tour, you might want to dip your toe into the waters by signing up for a few organized day trips. You?ll find you learn more and stress less with a professional tour guide. No worries about driving, directions, or parking?all you have to do is show up. Leaving the driving to others can be a great relationship saver, too. Driving in a foreign country with your partner navigating can lead to some serious friction. (Ask me how I know this!)

When You Absolutely Can?t Get Away

If financial restraints or personal obligations can make going away unrealistic, try a ?staycation." If possible, check into a local B&B, hotel, or resort. If not you can sleep at home. But play tourist for the day?avail yourself of the ?must-do? sites and experiences in your area that you rarely, or never, get around to. Even a 24 hour staycation can leave you greatly refreshed.

No Vacation? Try Meditation

When you find you need to get away right now, but it?s just not possible, give yourself a mini-break anytime you need one with meditation. If you haven?t meditated before, you?ll have more success using a guided meditation or brainwave entrainment MP3 to get started. Then go someplace quiet, get comfortable, and listen, using a headset or ear buds. You should feel emotionally lighter, refreshed, and more relaxed immediately. Do as needed whenever you could use a mini-vacation.

While meditation is one of the most beneficial habits you can incorporate into your daily life, it?s still not a substitute for a getting away. I recommend experiencing the benefits of both by being part of the ?Meditation and Vacation Nation?!

Don't Be Part of the "No Vacation Nation" | Pick the Brain


Deane Alban is co-founder of BeBrainFit.com and author of Brain Gold: The Anti-Aging Guide for Your Brain. She has taught and written on a wide variety of natural health topics for over 20 years. Her passion is teaching others how to rejuvenate their brains and overcome the common, but avoidable, problem of midlife mental decline.

Want to see your work on Lifehacker? Email Tessa.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/4qbPOW3Qu2w/how-to-avoid-becoming-part-of-no-vacation-nation-979446705

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বুধবার, ২৬ জুন, ২০১৩

Rdio updates its family plans, now allows up to five on one subscription

Android Central

Most expensive plan now $32.99 per month, limit increased from three people to five

Rdio, the popular music streaming service, has updated their family subscription plans to now allow up to five people to subscribe for one monthly payment. The previous plans only allowed for three different people, but thankfully those with slightly larger families can now take advantage. 

read more

    

Source: http://feedproxy.google.com/~r/androidcentral/~3/ZDAaPagpNio/story01.htm

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মঙ্গলবার, ২৫ জুন, ২০১৩

Hall of fame: Guy English, Louie Mantia, and Tap Tap Revenge

Hall of fame: Guy English, Louie Mantia, and Tap Tap Revenge

Last year we inducted Tap Tap Revolution and it's developer, Nate True into our inaugural iMore hall of fame. With TTR, True created what would become the first ever iOS-native gaming franchise. But it was only half the story. It wasn't True alone who transformed Tap Tap Revolution into Tap Tap Revenge, Tap Tap Dance, and everything that followed. True sold TTR to Tapulous, a company that, in 2008, was positively dripping in iPhone developer and designer talent. And two of the people who worked on it there, who helped make it the monstrous success it became, and who have gone on to help shape the industry, are Guy English and Louie Mantia.

In a "long boring history" post on Decremental, Tapulous founder Bart Decrem said:

Nate True and Guy English worked together on what would become Tap Tap Revenge 1.0. [...] The design for Tap Tap Revenge 1 was done by Louie Mantia. The product definition largely came from Nate, with contributions by Louie, Guy and myself. [...] On July 11, 2008, the App Store launched. Tap Tap Revenge was there on launch day and shot straight to #1.

The original engine for TTR was contained in a single source file. To move the game forward, Nate True and Tapulous decided they needed something more "extensible and beautiful". True wrote on the Tapulous Blog [via the Internet Archive:

Guy English and Mark Johns are the ones to thank for Tap Tap Revenge 2?s great new engine. Premiering in Tap Tap Dance, the new engine enables us to use way more effects in-game, giving you a more responsive, more beautiful, and fuller play experience. In Tap Tap Revenge 2, the engine has been vastly improved and features much more flexibility for the future.

Tap Tap Dance launched in 2008, and in March of 2009, Tapulous released Tap Tap Revenge 2, and re-released the original version as Tap Tap Classic. Many other versions followed before Tapulous sold to Disney in July of 2010.

Guy English

Guy English had been a game and app developer long before TTR and the app store. His background, as given on his website, Kickingbear:

For Tapulous I wrote the OpenGL engine, MIDI handling, Lua scripting and content pipeline for their Tap Tap Revenge series of games. Previously I have worked for Rogue Amoeba on Radioshift for the Mac and Radioshift Touch for iPhone as well as some other products. Before entering the Mac development community I spent many years writing code for video games on various platforms for various companies.

English is also responsible for helping ensure the graphics performance of, and generally kicking out the door and into the App Store, many other well-known apps that he's either not allowed, or not inclined to talk about. In addition, that willingness to help others, and to help the developer community, has manifested itself in other ways as well

In October of 2011, alongside Luc Vandal and Scott Morrison, English launched the ?ingleton Symposium. A yearly, single-track conference held in Montreal, ?ingleton brings together developers, designers, and members of the media to present and watch talks focused around a single, grand topic. Videos of the presentations are later made available on the ?ingleton Vimeo channel. The very first one was given by Daring Fireball's John Gruber:

Most recently, English teamed with Chris Parrish to form Aged & Distilled, and with Thomas Unterberger handling design, they launched Napkin. A Mac app with iPad-like direct manipulations, they billed it as concise visual communications, or more casually, #@(%!#* fast image annotation. It launched in January of 2013 and was featured by Apple on the Mac App Store.

Apps of the Week: Napkin, Mextures, Glassboard, and more

A frequent guest on John Gruber's The Talk Show, English also co-hosts two podcasts right here on Mobile Nations, Debug, which focuses on developers, and Ad Hoc, which features large panel discussions on movies, TV, and modern culture. He also continues to write on his Kickingbear blog.

Guy is a real treasure, one shared by the Apple development community. He truly loves helping other developers overcome obstacles and lending a helping hand. He never thinks twice about diving right in and giving you all of his attention and wisdom when you hit a roadblock. We've all benefited from the sage advice he has doled out over the years, and I am frequently blown away with the creative solutions he synthesizes to hard problems.
Chris Parrish, Aged & Distilled

Louie Mantia

In November of 2008, Louie Mantia joined the renowned Iconfactory. At the time, 2012 hall of fame inductee, Gedeon Maheux wrote on the Iconfactory blog:

Over the years, Louie has made a name for himself in the Mac icon and iPhone development communities. His work as one of the original Tapulous team members brought such iPhone favorites as Tap Tap Revenge and Fortune to the iTunes App Store. Louie also lead the user interface design on the critically acclaimed Obama ?08 iPhone application and has been a strong supporter of quality freeware on the Macintosh since day one.

One of the apps Mantia worked on at the Iconfactory was Ramp Champ. He shared his design process on his blog, Mantia.me:

I started designing the UI for the game, which is actually quite simple. There are four sections of the app, which you navigate with a tab bar. The first tab ?Play? lists the ramps you can play, ?Prizes? shows a booth of prizes that you can redeem your tickets for, and ?Loot? was your personal collection of prizes and trophies. Add-Ons came later.

Ramp Champ

From early on, Mantia's work showed an incredible attention to detail, a deep understanding of rich visual design, and flare for highly polished, highly usable interface and icons.

Mantia later went to Apple where he worked on icons for iAd Producer and Book Proofer, GarageBand's Organs and Guitars, the Trailers app, icons for Remote, WWDC, iBooks, GarageBand, Trailers, and the then-new icon for iTunes. He shared a little of the story behind the iTunes icon on Mantia.me:

When I was sixteen years old, I dreamed of a day that I?d be able to work at Apple, and when the day came that I got an email forwarded down to me from Steve about how the blue in the icon wasn?t beautiful enough, I knew I was living that dream.

iTunes and GarageBand

In 2012 Louie Mantia joined Brad Ellis and Jessie Char to found Pacific Helm, a San Francisco-based design studio dedicated to "shipping beautiful products that people love to use". Pacific Helm's work includes The Magazine, and icons for Mini Display, Summly, and many others.

In addition to client work, much of which remains confidential, Pacific Helm has released two of their own apps to the App Store. The first was Checkers, a simple, elegant checker set meant to be played offline, with another human.

The second, just recently released, is Camera Noir, a love-letter to the late, lamented Gotham filter.

Camera Noir from Pacific Helm gives you your Gotham back, with style!

Mantia has discussed his work, and his philosophy with us several times as a guest several on our Iterate podcast.

In between visits to Disney Land, Louie Mantia routinely adds free wallpapers to his website, Mantia.me, posts design concepts on his Dribbble page, and lights Twitter on fire with his opinions.

We are happy to take full credit for all of Louie Mantia's hard work.
Jessie Char and Brad Ellis, Pacific Helm

The work of Guy English and Louie Mantia may first have touched iPhone owners thanks to Tap Tap Revenge, but both of them have careers that far transcend any single app, and from bit to pixel, both have made iOS and OS X better platforms, and the community a better place. From blisteringly fast graphics to breathtaking icons, they've not only made fantastic apps, but helped make many of the apps we know and love even more fantastic.

That's why, as part of the 2013 hall of fame, we're honoring Guy English, Louie Mantia, and all of the apps they've applied their considerable talents too.

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/jexyEgVj5Tw/story01.htm

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In multiple sclerosis animal study, absence of gene leads to earlier, more severe disease

June 24, 2013 ? Scientists led by a UCSF neurology researcher are reporting that they have identified the likely genetic mechanism that causes some patients with multiple sclerosis (MS) to quickly progress to a debilitating stage of the disease while other patients progress much more slowly.

The team found that the absence of the gene Tob1 in CD4+ T cells, a type of immune cell, was the key to early onset of more serious disease in an animal model of MS.

Senior author Sergio Baranzini, PhD, a UCSF associate professor of neurology, said the finding may ultimately lead to the development of a test that predicts the course of MS in individual patients. Such a test could help physicians tailor personalized treatments, he said.

The study, done in collaboration with UCSF neurology researchers Scott Zamvil, MD, and Jorge Oksenberg, PhD, was published on June 24, 2013 in the Journal of Experimental Medicine.

MS is an inflammatory disease in which the protective myelin sheathing that coats nerve fibers in the brain and spinal cord is damaged and ultimately stripped away -- a process known as demyelination. During the highly variable course of the disease, a wide range of cognitive, debilitating and painful neurological symptoms can result.

In previously published work, Baranzini and his research team found that patients at an early stage of MS known as clinically isolated syndrome who expressed low amounts of Tob1 were more likely to exhibit further signs of disease activity -- a condition known as relapsing-remitting multiple sclerosis -- earlier than those who expressed normal levels of the gene.

The current study, according to Baranzini, had two goals: to recapitulate in an animal model what the researchers had observed in humans, and uncover the potential mechanism by which it occurs.

The authors were successful on both counts. They found that when an MS-like disease was induced in mice genetically engineered to be deficient in Tob1, the mice had significantly earlier onset compared with wild-type mice, and developed a more aggressive form of the disease.

Subsequent experiments revealed the probable cause: the absence of Tob1 in just CD4+ T cells. The scientists demonstrated this by transferring T cells lacking the Tob1 gene into mice that had no immune systems but had normal Tob1 in all other cells. They found that the mice developed earlier and more severe disease than mice that had normal Tob1 expression in all cells including CD4+.

"This shows that Tob1 only needs to be absent in this one type of immune cell in order to reproduce our initial observations in mice lacking Tob1 in all of their cells," said Baranzini.

The researchers also found the likely mechanism of disease progression in the Tob1-deficient mice: higher levels of Th1 and Th17 cells, which cause an inflammatory response against myelin, and lower levels of Treg cells, which normally regulate inflammatory responses. The inflammation results in demyelination.

The research is significant for humans, said Baranzini, because the presence or absence of Tob1 in CD4+ cells could eventually serve as a prognostic biomarker that could help clinicians predict the course and severity of MS in individual patients. "This would be useful and important," he said, "because physicians could decide to switch or modify therapies if they know whether the patient is likely to have an aggressive course of disease, or a more benign course."

Ultimately, predicted Baranzini, "This may become an example of personalized medicine. When the patient comes to the clinic, we will be able to tailor the therapy based on what the tests tell us. We're now laying the groundwork for this to happen."

Co-authors of the study are Ulf Schulze-Topphoff, PhD, of UCSF; Simona Casazza, PhD, of UCSF at the time of the study; Michel Varrin-Doyer, PhD; and Kara Pekarek of UCSF; Raymond A. Sobel, MD, of Stanford University School of Medicine, and Stephen L. Hauser, MD, of UCSF.

The study was supported by funds from the National Institutes of Health (R01 grants NS26799, NS049477, AI073737, AI059709 and NS063008), the National Multiple Sclerosis Society, the Robert Tillman Family Fund, the Guthy-Jackson Charitable Foundation and the Maisin Foundation.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/b9pqL_poK-s/130624093411.htm

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Singapore to Indonesia: Stop sending us your smog.

Air pollution in Singapore?rose to unhealthy levels this week because of illegal forest clearing in Indonesia,?prompting?Singapore?to urge Indonesia to do something to end the haze.

By Sara Schonhardt,?Correspondent / June 20, 2013

A masked man walks as the sun sets among buildings covered with haze at the Singapore Central Business District Thursday, June 20, 2013. Singapore urged people to remain indoors amid unprecedented levels of air pollution Thursday as a smoky haze wrought by forest fires in neighboring Indonesia worsened dramatically.

Joseph Nair/AP

Enlarge

Cloudy skies in Jakarta were no match for the breathtaking haze that hit Singapore?on Thursday?as air-pollution levels rose to record highs and sparked a war of words between diplomats in both countries over who should shoulder the blame.

Skip to next paragraph Sara Schonhardt

Indonesia Correspondent

Sara Schonhardt is a Monitor contributor based in Jakarta, Indonesia, where she has been reporting since 2009.?Sara previously worked for various media in Thailand and Cambodia and received her master?s degree from the School of International and Public Affairs at Columbia University.

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Companies have asked employees to work from home, the military has stopped training outdoors, and pictures of Singapore's iconic Marine Bay Sands towers barely visible through the haze have been splashed across social media platforms?and newspapers.

Despite the international blame game, the immediate cause was clear enough: fires used to clear land in Sumatra for farming and palm oil plantations. A local meteorological agency reported nearly 150 hotspots alone in Riau Province, itself a hotspot for mining, logging, and palm oil production.

Environmental advocacy group Greenpeace released a statement saying that the fires illustrated how Indonesia?s government policies aimed at reducing deforestation had failed?since half of them were in areas off-limits to land clearing.

Each year slash and burn practices in Indonesia shroud neighboring Singapore and Malaysia in thick haze. As deforestation has accelerated in recent years, it has worsened.

On Thursday,?Singapore sent a delegation from its environmental agency to Jakarta to call for immediate action.?Singapore?s environment minister, Vivian Balakrishnan, issued an angry statement?on his Facebook page saying no country or corporation ?has the right to pollute the air at the expense of Singaporeans? health and well-being.??

But Indonesia shot back its own statement: Singapore should stop ?behaving like a child,? said Indonesia?s?Coordinating Minister for People's Welfare, Agung Laksono, who oversees fire response.

Mr. Balakrishnan had asked the Indonesian government to name and shame the companies involved in the illegal burning. But Indonesia?s forestry ministry launched back, saying?Singapore and Malaysia shared the responsibility for putting pressure on the resource extraction industry since many of companies were based in their countries.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/DSOCJEKKLvY/Singapore-to-Indonesia-Stop-sending-us-your-smog

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